Increased Sperm DNA Damage in Experimental Rat Varicocele Model and The Beneficial Effect of Varicocelectomy

increased sperm dna damage in experimental rat varicocele model and the beneficial effect of varicocelectomy

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Increased Sperm DNA Damage in Experimental Rat Varicocele Model and The Beneficial Effect of Varicocelectomy

BACKGROUND Varicocele, the abnormal dilatation of the veins in the pampiniform plexus is commonly seen in infertile patients. In this study, we aim to examine sperm DNA damage after the creation of experimental varicocele in rats and to observe the change of this damage after a varicocelectomy. MATERIALS AND METHODS In this experimental study, a total of 30 adult male Wistar albino rats were ...

Beneficial effect of microsurgical varicocelectomy on human sperm DNA integrity.

BACKGROUND Human sperm DNA damage may adversely affect reproductive outcomes, and the spermatozoa of infertile men possess substantially more DNA damage than that of fertile men. To date, there is no available treatment for men with high levels of sperm DNA damage. The objective of this study was to examine the effect of varicocelectomy on sperm DNA denaturation (DD, an index of sperm DNA damag...

Origin and Role of DNA Damage in Varicocele

The Beneficial Effect of (-)-Epigallocatechin-3-Gallate in an Experimental Model of Alzheimer’s disease in Rat: a Behavioral Analysis

Progressive cognitive decline is one of the hallmark symptoms of Alzheimer’s disease (AD) which can be modeled by β-amyloid injection into specific regions of brain. Since epigallocatechin-3-gallate (EGCG) is a potent antioxidant agent which its role against oxidative stress and inflammation has been shown in prior studies, we tried to determine whether EGCG administration protects against β-am...

P-5: Assessment of Sperm Chromatin Status in Rat Experimental Varicocele

Background: Varicocele is considered as a common cause of male infertility and can affect spermatogenesis. In addition, it also predisposed sperm to chromatin damage and morphological alternation. Other factors, such as environmental and genetic conditions also predispose sperm to these conditions. To answer this question, we aimed to evaluation of DNA fragmentation and protamine deficiency thr...